A Randomized Clinical Trial of Behavioral Activation (BA) Therapy for Improving Psychological and Physical Health in Dementia Caregivers: Results of the Pleasant Events Program (PEP)
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122A Randomized Clinical Trial of Behavioral Activation (BA) Therapy for Improving Psychological and Physical Health in Dementia Caregivers: Results of the Pleasant Events Program (PEP)
Auteurs : Raeanne C. Moore ; Elizabeth A. Chattillion ; Jennifer Ceglowski ; Jennifer Ho ; Roland Von K Nel [Suisse] ; Paul J. Mills ; Michael G. Ziegler ; Thomas L. Patterson ; Igor Grant ; Brent T. MausbachSource :
- Behaviour research and therapy [ 0005-7967 ] ; 2013.
Abstract
Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention (N=49) or a time-equivalent Information-Support (IS) control condition (N=51). Assessments were completed pre- and post-intervention and at 1-year follow-up. Biological assessments included CVD risk markers Interleukin-6 (IL-6) and D-dimer. Psychosocial outcomes included depressive symptoms, positive affect, and negative affect. Participants receiving the PEP intervention had significantly greater reductions in IL-6 (p=.040), depressive symptoms (p=.039), and negative affect (p=.021) from pre- to post-treatment. For IL-6, clinically significant improvement was observed in 20.0% of PEP participants and 6.5% of IS participants. For depressive symptoms, clinically significant improvement was found for 32.7% of PEP vs 11.8% of IS participants. Group differences in change from baseline to 1-year follow-up were non-significant for all outcomes. The PEP program decreased depression and improved a measure of physiological health in older dementia caregivers. Future research should examine the efficacy of PEP for improving other CVD biomarkers and seek to sustain the intervention’s effects.
Url:
DOI: 10.1016/j.brat.2013.07.005
PubMed: 23916631
PubMed Central: 3774137
Affiliations:
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Mills</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff><wicri:noCountry code="subfield">University of California San Diego</wicri:noCountry></affiliation></author><author><name sortKey="Ziegler, Michael G" sort="Ziegler, Michael G" uniqKey="Ziegler M" first="Michael G" last="Ziegler">Michael G. Ziegler</name><affiliation><nlm:aff id="A6">Department of Medicine, University of California San Diego</nlm:aff><wicri:noCountry code="subfield">University of California San Diego</wicri:noCountry></affiliation></author><author><name sortKey="Patterson, Thomas L" sort="Patterson, Thomas L" uniqKey="Patterson T" first="Thomas L" last="Patterson">Thomas L. Patterson</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff><wicri:noCountry code="subfield">University of California San Diego</wicri:noCountry></affiliation></author><author><name sortKey="Grant, Igor" sort="Grant, Igor" uniqKey="Grant I" first="Igor" last="Grant">Igor Grant</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff><wicri:noCountry code="subfield">University of California San Diego</wicri:noCountry></affiliation></author><author><name sortKey="Mausbach, Brent T" sort="Mausbach, Brent T" uniqKey="Mausbach B" first="Brent T" last="Mausbach">Brent T. Mausbach</name><affiliation><nlm:aff id="A1">Department of Psychiatry, University of California San Diego</nlm:aff><wicri:noCountry code="subfield">University of California San Diego</wicri:noCountry></affiliation></author></analytic><series><title level="j">Behaviour research and therapy</title><idno type="ISSN">0005-7967</idno><idno type="eISSN">1873-622X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Dementia caregiving is associated with elevations in depressive symptoms and increased risk for cardiovascular diseases (CVD). This study evaluated the efficacy of the Pleasant Events Program (PEP), a 6-week Behavioral Activation intervention designed to reduce CVD risk and depressive symptoms in caregivers. One hundred dementia family caregivers were randomized to either the 6-week PEP intervention (N=49) or a time-equivalent Information-Support (IS) control condition (N=51). Assessments were completed pre- and post-intervention and at 1-year follow-up. Biological assessments included CVD risk markers Interleukin-6 (IL-6) and D-dimer. Psychosocial outcomes included depressive symptoms, positive affect, and negative affect. Participants receiving the PEP intervention had significantly greater reductions in IL-6 (p=.040), depressive symptoms (p=.039), and negative affect (p=.021) from pre- to post-treatment. For IL-6, clinically significant improvement was observed in 20.0% of PEP participants and 6.5% of IS participants. For depressive symptoms, clinically significant improvement was found for 32.7% of PEP vs 11.8% of IS participants. Group differences in change from baseline to 1-year follow-up were non-significant for all outcomes. The PEP program decreased depression and improved a measure of physiological health in older dementia caregivers. Future research should examine the efficacy of PEP for improving other CVD biomarkers and seek to sustain the intervention’s effects.</p></div></front></TEI><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Berne</li></region><settlement><li>Berne</li></settlement><orgName><li>Université de Berne</li></orgName></list><tree><noCountry><name sortKey="Ceglowski, Jennifer" sort="Ceglowski, Jennifer" uniqKey="Ceglowski J" first="Jennifer" last="Ceglowski">Jennifer Ceglowski</name><name sortKey="Chattillion, Elizabeth A" sort="Chattillion, Elizabeth A" uniqKey="Chattillion E" first="Elizabeth A" last="Chattillion">Elizabeth A. Chattillion</name><name sortKey="Grant, Igor" sort="Grant, Igor" uniqKey="Grant I" first="Igor" last="Grant">Igor Grant</name><name sortKey="Ho, Jennifer" sort="Ho, Jennifer" uniqKey="Ho J" first="Jennifer" last="Ho">Jennifer Ho</name><name sortKey="Mausbach, Brent T" sort="Mausbach, Brent T" uniqKey="Mausbach B" first="Brent T" last="Mausbach">Brent T. Mausbach</name><name sortKey="Mills, Paul J" sort="Mills, Paul J" uniqKey="Mills P" first="Paul J" last="Mills">Paul J. Mills</name><name sortKey="Moore, Raeanne C" sort="Moore, Raeanne C" uniqKey="Moore R" first="Raeanne C" last="Moore">Raeanne C. Moore</name><name sortKey="Patterson, Thomas L" sort="Patterson, Thomas L" uniqKey="Patterson T" first="Thomas L" last="Patterson">Thomas L. Patterson</name><name sortKey="Ziegler, Michael G" sort="Ziegler, Michael G" uniqKey="Ziegler M" first="Michael G" last="Ziegler">Michael G. Ziegler</name></noCountry><country name="Suisse"><noRegion><name sortKey="Von K Nel, Roland" sort="Von K Nel, Roland" uniqKey="Von K Nel R" first="Roland" last="Von K Nel">Roland Von K Nel</name></noRegion><name sortKey="Von K Nel, Roland" sort="Von K Nel, Roland" uniqKey="Von K Nel R" first="Roland" last="Von K Nel">Roland Von K Nel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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